Drug Design of Zinc-Enzyme Inhibitors

Wiley Series in Drug Discovery and Development

Claudiu T. Supuran, Jean-Yves Winum, Binghe Wang

Drug Design of Zinc-Enzyme Inhibitors
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Product details

Published22nd October 2009
ISBN9780470508152
Price£169.00
Print ISBN9780470275009
eISBN9780470508152
Authors, ,
PublisherWiley
Edition1st edition
Pages1072
LanguageEnglish
Subjects:Pharmacology
BIC:MMG
BISAC:MED071000
123Library ID:4520
Format:eBook

eBook Overview

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes

The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context.

With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as:

  • Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G

  • Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions

  • Cross reactivity of zinc-enzyme inhibitors and activators

  • The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins

  • Clinical applications

An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.

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Table of Contents

DRUG DESIGN OF ZINC-ENZYME INHIBITORS
citation
3
CONTENTS7
PREFACE11
CONTRIBUTORS
citation
13
PART I INTRODUCTION
citation
19
1. Introduction to Zinc Enzymes as Drug Targets
citation
21
PART II DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS
citation
31
2. Carbonic Anhydrases as Drug Targets: General Presentation
citation
33
3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors
citation
57
4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design
citation
91
5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs
citation
157
6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs
citation
173
7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents
citation
189
8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII
citation
211
9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX
citation
241
10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors
citation
259
11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition
citation
273
12. Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV
citation
291
13. Mechanism and Inhibition of the β-Class and γ-Class Carbonic Anhydrases
citation
303
14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design
citation
319
15. Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development
citation
341
16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria
citation
353
17. Inhibitors of Helicobacter pylori α- and β-Carbonic Anhydrases as Novel Drugs for Gastroduodenal Diseases
citation
377
18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design
citation
393
19. Selectivity Issues in the Design of CA Inhibitors
citation
417
20. Bicarbonate Transport Metabolons
citation
433
21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors
citation
457
22. Drug Design Studies of Carbonic Anhydrase Activators
citation
491
PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE INHIBITORS
citation
505
23. Matrix Metalloproteinases: An Overview
citation
507
24. MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches
citation
537
25. Drug Design of Sulfonylated MMP Inhibitors
citation
567
26. ADAMs and ADAMTs Selective Synthetic Inhibitors
citation
609
27. QSAR Studies of MMP Inhibitors
citation
665
PART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE INHIBITORS
citation
691
28. Bacterial Zinc Proteases as Orphan Targets
citation
693
29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors
citation
723
30. Clostridium histolyticum Collagenase Inhibitors in the Drug Design
citation
739
31. Other Bacterial Zinc Peptidases as Potential Drug Targets
citation
749
PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING ENZYMES
citation
767
32. Angiotensin Converting Enzyme (ACE) Inhibitors
citation
769
33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucurus Venom: Isolation and Possible Inhibition
citation
807
34. CaaX-Protein Prenyltransferase Inhibitors
citation
831
35. Histone Deacetylase Inhibitors
citation
877
36. Recent Development of Diagnostic and Therapeutic Agents Targeting Glutamate Carboxypeptidase II (GCPII)
citation
899
37. Targeting HIV-1 Integrase Zinc Binding Motif
citation
929
38. Inhibitors of Histidinol Dehydrogenases as Antibacterial Agents
citation
955
39. Dihydroorotase Inhibitors
citation
969
40. APOBEC3G: A Promising Antiviral Target
citation
999
Index1007