Fatty Acid and Lipotoxicity in Obesity and Diabetes

Novartis Foundation Symposia

Fatty Acid and Lipotoxicity in Obesity and Diabetes
Preview this ebook

Product details

Published11th March 2008
ISBN9780470985564
Price£100.00
Print ISBN9780470057643
eISBN9780470985564
PublisherWiley
Edition1st edition
Pages223
LanguageEnglish
Subjects:Endocrinology
Thema 1.1:MJG
BIC 2.1:MJG
BISAC:MED027000
123Library ID:3760
Format:eBook

eBook Overview

The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle.

This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

Search inside this book:

Table of Contents

FATTY ACIDS AND LIPOTOXICITY IN OBESITY AND DIABETES1
Contents7
Chair’s introduction13
Transcriptional control of energy homeostasis through the PGC1 coactivators15
DISCUSSION18
Human obesity and insulin resistance: lessons from experiments of nature25
DISCUSSION32
Lipid-induced metabolic dysfunction in skeletal muscle36
DISCUSSION50
Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes59
DISCUSSION66
The role of lipin 1 in adipogenesis and lipid metabolism70
DISCUSSION80
The role of the AMP-activated protein kinase in the regulation of energy homeostasis84
DISCUSSION93
Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes98
DISCUSSION106
The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis111
DISCUSSION121
Fatty acid transport in adipocytes and the development of insulin resistance125
DISCUSSION133
Vectorial acylation: linking fatty acid transport and activation to metabolic trafficking139
DISCUSSION150
Lipid storage and mobilization pathways in yeast154
DISCUSSION163
Cide proteins and the development of obesity167
DISCUSSION171
General discussion I174
Visualizing brown adipose tissue with FDG-PET174
Adiponectin and adiponectin receptors in obesity-linked insulin resistance176
DISCUSSION188
Anti-inflammatory and antidiabetic roles of PPARy195
DISCUSSION208
Final Discussion212
Nutrition, ageing and lipotoxicity212
Contributor Index216
Subject Index218