Fatty Acid and Lipotoxicity in Obesity and Diabetes

Novartis Foundation Symposia

Fatty Acid and Lipotoxicity in Obesity and Diabetes
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Product details

Published11th March 2008
ISBN9780470985564
Price£100.00
Print ISBN9780470057643
eISBN9780470985564
PublisherWiley
Edition1st edition
Pages223
LanguageEnglish
Subjects:Endocrinology
BIC:MJG
BISAC:MED027000
123Library ID:3760
Format:eBook

eBook Overview

The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle.

This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

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Table of Contents

FATTY ACIDS AND LIPOTOXICITY IN OBESITY AND DIABETES
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1
Contents7
Chair’s introduction
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13
Transcriptional control of energy homeostasis through the PGC1 coactivators
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15
DISCUSSION
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18
Human obesity and insulin resistance: lessons from experiments of nature
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25
DISCUSSION
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32
Lipid-induced metabolic dysfunction in skeletal muscle
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36
DISCUSSION
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50
Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes
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59
DISCUSSION
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66
The role of lipin 1 in adipogenesis and lipid metabolism
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70
DISCUSSION
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80
The role of the AMP-activated protein kinase in the regulation of energy homeostasis
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84
DISCUSSION
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93
Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes
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98
DISCUSSION
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106
The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis
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111
DISCUSSION
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121
Fatty acid transport in adipocytes and the development of insulin resistance
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125
DISCUSSION
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133
Vectorial acylation: linking fatty acid transport and activation to metabolic trafficking
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139
DISCUSSION
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150
Lipid storage and mobilization pathways in yeast
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154
DISCUSSION
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163
Cide proteins and the development of obesity
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167
DISCUSSION
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171
General discussion I
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174
Visualizing brown adipose tissue with FDG-PET
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174
Adiponectin and adiponectin receptors in obesity-linked insulin resistance
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176
DISCUSSION
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188
Anti-inflammatory and antidiabetic roles of PPARy
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195
DISCUSSION
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208
Final Discussion
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212
Nutrition, ageing and lipotoxicity
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212
Contributor Index216
Subject Index218